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Whereas TNF-?is potentially cytotoxic, as it is able to induce an apoptotic response, it is also well-recognized that this cytokine can promote tumorigenesis through the activation ofNF- ?B on a background of in? ammation [ 44 , 45].

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Much more than just a hairdo, he is hip and groin. He was one of the founding members of the now defunct, and believes that disco music was made to make you dance. He once wore a pair of shoes, and nothing will stop him from breathing but sweet, sweet death.


  • Mr Downe!

    I get your anger. Fred Phelps is a piece of work and represents the pinnacle of some of the most disgusting possible points of view.

    Is he worth the vitriol? Everything the man stands for is abhorrent – yet rational people can and do make rational decisions everyday and remain unaffected by this guy. I think Fred has long been beyond saving; and I would be more scared if that church/organization had intelligent people working for them that had the capacity to engage mainstream support.

    I don’t agree with censorship though Downey, – I will always rather live in a country where you hear about these views because free speech is a gift even if it is abused. Exposing those views is what allows consensus to continue to behave decently. Your last paragraph irked me a bit, but I do not deny your right to hate the guy. People like him are not a problem unique to the USA and the need for introspection is not exclusively American.

  • Drury, thank you for your comment and I apologise for insulting your apparent nationalistic love for the US of A, but you have highlighted the basic issue I have with this whole thing. Freedom of speech, while comforting for those who believe themselves to be liberal, can be very destructive. Because of man’s lack of control, we require laws to be enacted so that we can live as peacefully and safely as possible, together, as a community. Why should speech be held to a higher degree? Look at what a belief in freedom of speech has done to the media in America; it has created a farce of journalism and turned newspapers into gossip magazines. Religion is the same; it has turned into an untouchable force that has spiraled into a hurricane of hurt. Speech and religion should be regulated. Not to discourage individualism or thought, but to encourage rationalism and consideration. Because when you have a higher degree of rational and considerate populations, then shall thrive individualism and thought but at greater intellectual level. Perhaps we can finally live in a world where ‘think before you speak’ is a truth and not just a concept.

    • Mr Downe – my love knows no bounds or boundaries except for Norwich; or the ‘other’ side of North London and that’s only on Saturday’s at 3:00pm or thereabouts.

      You’re right I did highlight the real issue. Fred Phelps is a caricature of both religion and the anti-gay stance, and he remains that in death. His idiocy has help to promote the cause and create support for gay rights – he is the best thing that could have happened, because his ‘free speech’ as was, served to highlight how ridiculous the polar stances he represented were. Even his own son could not reconcile himself with his fathers views. The guy got his desserts.

      Without free speech what might we get? Suppression of issues. Toeing the line. No platform for whistleblowers or for the leaking of information to be supported. We actually get more kowtowing to religious doctrine, we get less impetus to question. We get limited discussion and limited debate, which is the real farce of the journalism you point to as leverage.

      As for religion, you cannot police belief or faith. You can legislate for what people physically do, and depending where you are in the world the legislation helps you, and some places it doesn’t; and you can choose to defend belief or not.

      A key issue I feel where religion becomes a problem is its role cultures where the state uses it (religion) as the vehicle for suppressive legislation. Those by the way, are also countries that typically have strict laws regarding freedom of speech.

      Enjoy your affogato.

  • SARAH! I love tha tyou took off the sleeves. Not that th#&1e82y7;re not cute, but I think it is an improvement and keeps it in the Mad Men style for sure. Also glad to see that it looks good on a curvy girl too, since that is why I hesitated and didn’t buy it yet. Also, your haircut looks fabulous with this dress!

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